产品名称
Melan-A Rabbit Polyclonal Antibody
别名
MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
蛋白名称
Melanoma antigen recognized by T-cells 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2315
Human Swissprot No.
Q16655
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16655/entry
免疫原
The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90
特异性
Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
组织表达
Expression is restricted to melanoma and melanocyte cell lines and retina.
细胞定位
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
功能
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
