产品名称
MEL-1B-R Rabbit Polyclonal Antibody
别名
MTNR1B; Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor
蛋白名称
Melatonin receptor type 1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4544
Human Swissprot No.
P49286
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49286/entry
Mouse Swissprot No.
Q8CIQ6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CIQ6
免疫原
The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350
特异性
MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],
组织表达
Expressed in retina and less in brain and hippocampus.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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