产品名称
MEK-4 Rabbit Polyclonal Antibody
别名
MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
蛋白名称
Dual specificity mitogen-activated protein kinase kinase 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6416
Human Swissprot No.
P45985
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P45985/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26398
Mouse Swissprot No.
P47809
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47809
免疫原
The antiserum was produced against synthesized peptide derived from human SEK1/MKK4. AA range:46-95
特异性
MEK-4 Polyclonal Antibody detects endogenous levels of MEK-4 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
细胞定位
Cytoplasm . Nucleus .
信号通路
Regulates Angiogenesis; Stem cell pathway; Regulation of Actin Dynamics; Toll_Like; Cell Growth; ErbB/HER; B Cell Receptor; MAPK_ERK_Growth;MAPK_G_Protein
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SPAG9.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
