BD-PT2717

MEK-3 Rabbit Polyclonal Antibody

MAP2K3; MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2

常规抗体

MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5606

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5606

P46734

http://www.uniprot.org/uniprotkb/P46734/entry

26397

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26397

O09110

http://www.uniprot.org/uniprot/O09110

The antiserum was produced against synthesized peptide derived from human MAP2K3. AA range:188-237

MEK-3 Polyclonal Antibody detects endogenous levels of MEK-3 protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

39kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

nucleoplasm,cytoplasm,cytosol,membrane,

Regulates Angiogenesis; Stem cell pathway; Regulation of Actin Dynamics; Toll_Like; Cell Growth; MAPK_ERK_Growth;MAPK_G_Protein; B Cell Receptor

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K3 may be involved in colon cancer.,enzyme regulation:Activated by dual phosphorylation on Ser-218 and Thr-222.,function:Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.,PTM:Autophosphorylated.,PTM:Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with Yersinia yopJ.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.