产品名称
MEF-2B Rabbit Polyclonal Antibody
别名
MEF2B; XMEF2; Myocyte-specific enhancer factor 2B; RSRFR2; Serum response factor-like protein 2
蛋白名称
Myocyte-specific enhancer factor 2B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4207
Human Swissprot No.
Q02080
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02080/entry
Mouse Swissprot No.
O55087
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55087
免疫原
The antiserum was produced against synthesized peptide derived from human MEF2B. AA range:51-100
特异性
MEF-2B Polyclonal Antibody detects endogenous levels of MEF-2B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010],
组织表达
Expressed in skeletal and cardiac muscle and brain.
信号通路
AMPK; Protein_Acetylation
功能
function:Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.,similarity:Belongs to the MEF2 family.,similarity:Contains 1 MADS-box domain.,similarity:Contains 1 Mef2-type DNA-binding domain.,subunit:Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9.,tissue specificity:Expressed in skeletal and cardiac muscle and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
