产品名称
ME3 Rabbit Polyclonal Antibody
别名
ME3; NADP-dependent malic enzyme; mitochondrial; NADP-ME; Malic enzyme 3
蛋白名称
NADP-dependent malic enzyme mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10873
Human Swissprot No.
Q16798
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16798/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109264
Mouse Swissprot No.
Q8BMF3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BMF3
免疫原
The antiserum was produced against synthesized peptide derived from human ME3. AA range:545-594
特异性
ME3 Polyclonal Antibody detects endogenous levels of ME3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed predominantly in organs with a low-division rate.
细胞定位
Mitochondrion matrix.
信号通路
Pyruvate metabolism;
功能
catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,similarity:Belongs to the malic enzymes family.,tissue specificity:Expressed predominantly in organs with a low-division rate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
