产品名称
ME2 Rabbit Polyclonal Antibody
别名
ME2; NAD-dependent malic enzyme; mitochondrial; NAD-ME; Malic enzyme 2
蛋白名称
NAD-dependent malic enzyme mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4200
Human Swissprot No.
P23368
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23368/entry
Mouse Swissprot No.
Q99KE1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99KE1
免疫原
The antiserum was produced against synthesized peptide derived from human ME2. AA range:201-250
特异性
ME2 Polyclonal Antibody detects endogenous levels of ME2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009],
组织表达
B-cell,Placenta,Platelet,
细胞定位
Mitochondrion matrix .
信号通路
Pyruvate metabolism;
功能
catalytic activity:(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,enzyme regulation:Subject to allosteric activation by fumarate.,miscellaneous:This isoenzyme can also use NADP(+) but is more effective with NAD(+).,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
