产品名称
MCT4 Rabbit Polyclonal Antibody
别名
SLC16A3; MCT4; Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3
蛋白名称
Monocarboxylate transporter 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9123
Human Swissprot No.
O15427
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15427/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80879
Mouse Swissprot No.
P57787
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P57787
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80878
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35910
免疫原
The antiserum was produced against synthesized peptide derived from human MOT4. AA range:233-282
特异性
MCT4 Polyclonal Antibody detects endogenous levels of MCT4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in skeletal muscle.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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