产品名称
Cleaved-GGT4 HC (T472) Rabbit Polyclonal Antibody
别名
GGT7; GGTL3; GGTL5; Gamma-glutamyltransferase 7; GGT 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7; Glutathione hydrolase 7
蛋白名称
Gamma-glutamyltransferase 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2686
Human Swissprot No.
Q9UJ14
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UJ14/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=207182
Mouse Swissprot No.
Q99JP7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JP7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=156275
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99MZ4
免疫原
The antiserum was produced against synthesized peptide derived from human Gamma-glutamyltransferase 4. AA range:423-472
特异性
Cleaved-GGT4 HC (T472) Polyclonal Antibody detects endogenous levels of fragment of activated GGT4 HC protein resulting from cleavage adjacent to T472.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
细胞定位
Membrane ; Single-pass type II membrane protein .
信号通路
Taurine and hypotaurine metabolism;Selenoamino acid metabolism;Cyanoamino acid metabolism;Glutathione metabolism;Arachidonic acid metabolism;
功能
catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,function:Cleaves glutathione conjugates.,pathway:Sulfur metabolism; glutathione metabolism.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.,tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
