产品名称
MC5-R Rabbit Polyclonal Antibody
别名
MC5R; Melanocortin receptor 5; MC5-R; MC-2
蛋白名称
Melanocortin receptor 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4161
Human Swissprot No.
P33032
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P33032/entry
Mouse Swissprot No.
P41149
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P41149
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25726
Rat Swissprot Link
http://www.uniprot.org/uniprot/P35345
免疫原
The antiserum was produced against synthesized peptide derived from human MC5R. AA range:271-320
特异性
MC5-R Polyclonal Antibody detects endogenous levels of MC5-R protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010],
组织表达
Expressed in the brain but not in the melanoma cells.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the brain but not in the melanoma cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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