产品名称
MC4-R Rabbit Polyclonal Antibody
别名
MC4R; Melanocortin receptor 4; MC4-R
蛋白名称
Melanocortin receptor 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4160
Human Swissprot No.
P32245
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P32245/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17202
Mouse Swissprot No.
P56450
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56450
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25635
Rat Swissprot Link
http://www.uniprot.org/uniprot/P70596
免疫原
The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330
特异性
MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],
组织表达
Brain, placental, and gut tissues.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
