产品名称
MaxiKβ2 Rabbit Polyclonal Antibody
别名
KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K cha
蛋白名称
Calcium-activated potassium channel subunit beta-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10242
Human Swissprot No.
Q9Y691
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y691/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72413
Mouse Swissprot No.
Q9CZM9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZM9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294961
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q811Q0
免疫原
The antiserum was produced against synthesized peptide derived from human KCNMB2. AA range:151-200
特异性
MaxiKβ2 Polyclonal Antibody detects endogenous levels of MaxiKβ2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013],
组织表达
Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
细胞定位
Membrane; Multi-pass membrane protein.
信号通路
Vascular smooth muscle contraction;
功能
domain:The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.,function:Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.,PTM:N-glycosylated.,similarity:Belongs to the KCNMB family.,subunit:Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.,tissue specificity:Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
