产品名称
MARCH3 Rabbit Polyclonal Antibody
别名
MARCH3; RNF173; E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; MARCH-III; RING finger protein 173
蛋白名称
E3 ubiquitin-protein ligase MARCH3
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115123
Human Swissprot No.
Q86UD3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86UD3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320253
Mouse Swissprot No.
Q8BRX9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BRX9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=364878
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5XIE5
免疫原
The antiserum was produced against synthesized peptide derived from human MARCH3. AA range:111-160
特异性
MARCH3 Polyclonal Antibody detects endogenous levels of 40605 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013],
细胞定位
Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
功能
domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MARCH2 and STX6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
