产品名称
MAP-2 Rabbit Polyclonal Antibody
别名
MAP2; Microtubule-associated protein 2; MAP-2
蛋白名称
Microtubule-associated protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4133
Human Swissprot No.
P11137
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P11137/entry
Mouse Swissprot No.
P20357
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20357
Rat Swissprot Link
http://www.uniprot.org/uniprot/P15146
免疫原
The antiserum was produced against synthesized peptide derived from human MAP-2. AA range:14-63
特异性
MAP-2 Polyclonal Antibody detects endogenous levels of MAP-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
组织表达
Brain,Brain cortex,Epithelium,Pancreas,Testis,
细胞定位
Cytoplasm, cytoskeleton . Cell projection, dendrite .
功能
alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
