BD-PT2635

MAO-A Rabbit Polyclonal Antibody

MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A

常规抗体

MAOA

Amine oxidase [flavin-containing] A

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4128

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4128

P21397

http://www.uniprot.org/uniprotkb/P21397/entry

17161

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17161

Q64133

http://www.uniprot.org/uniprot/Q64133

P21396

http://www.uniprot.org/uniprot/P21396

The antiserum was produced against synthesized peptide derived from human MAO-A. AA range:298-347

MAO-A Polyclonal Antibody detects endogenous levels of MAO-A protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

61kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],

Heart, liver, duodenum, blood vessels and kidney.

Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .

Glycine; serine and threonine metabolism;Arginine and proline metabolism;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Drug metabolism;

catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.,tissue specificity:Heart, liver, duodenum, blood vessels and kidney.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.