产品名称
Manic Fringe Rabbit Polyclonal Antibody
别名
MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
蛋白名称
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4242
Human Swissprot No.
O00587
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O00587/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17305
Mouse Swissprot No.
O09008
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O09008
免疫原
The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110
特异性
Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009],
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
