产品名称
MALT1 Rabbit Polyclonal Antibody
别名
MALT1; MLT; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; MALT lymphoma-associated translocation; Paracaspase
蛋白名称
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10892
Human Swissprot No.
Q9UDY8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UDY8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=240354
Mouse Swissprot No.
Q2TBA3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q2TBA3
免疫原
The antiserum was produced against synthesized peptide derived from human MALT1. AA range:301-350
特异性
MALT1 Polyclonal Antibody detects endogenous levels of MALT1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
细胞定位
Cytoplasm, perinuclear region . Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. .
信号通路
T_Cell_Receptor;B_Cell_Antigen;
功能
disease:A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,function:Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.,similarity:Belongs to the peptidase C14B family.,similarity:Contains 1 death domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.,subunit:Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.,tissue specificity:Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
