产品名称
Malic enzyme 1 Rabbit Polyclonal Antibody
别名
ME1; NADP-dependent malic enzyme; NADP-ME; Malic enzyme 1
蛋白名称
NADP-dependent malic enzyme
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4199
Human Swissprot No.
P48163
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48163/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17436
Mouse Swissprot No.
P06801
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P06801
Rat Swissprot Link
http://www.uniprot.org/uniprot/P13697
免疫原
The antiserum was produced against synthesized peptide derived from human ME1. AA range:468-517
特异性
Malic enzyme 1 Polyclonal Antibody detects endogenous levels of Malic enzyme 1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues tested including liver, placenta and white adipose tissue.
信号通路
Pyruvate metabolism;PPAR;
功能
catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,tissue specificity:Expressed in all tissues tested including liver, placenta and white adipose tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
