产品名称
MAK Rabbit Polyclonal Antibody
别名
MAK; Serine/threonine-protein kinase MAK; Male germ cell-associated kinase
蛋白名称
Serine/threonine-protein kinase MAK
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4117
Human Swissprot No.
P20794
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20794/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17152
Mouse Swissprot No.
Q04859
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q04859
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25677
Rat Swissprot Link
http://www.uniprot.org/uniprot/P20793
免疫原
The antiserum was produced against synthesized peptide derived from human MAK. AA range:126-175
特异性
MAK Polyclonal Antibody detects endogenous levels of MAK protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
组织表达
Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
细胞定位
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Could play an important function in spermatogenesis.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed mainly in testicular cells at and after meiosis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
