产品名称
MAD2L1BP Rabbit Polyclonal Antibody
别名
MAD2L1BP; CMT2; KIAA0110; MAD2L1-binding protein; Caught by MAD2 protein
蛋白名称
MAD2L1-binding protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9587
Human Swissprot No.
Q15013
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15013/entry
Mouse Swissprot No.
Q9DCX1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCX1
免疫原
Synthesized peptide derived from MAD2L1BP . at AA range: 10-90
特异性
MAD2L1BP Polyclonal Antibody detects endogenous levels of MAD2L1BP protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Lung,
细胞定位
Nucleus. Cytoplasm, cytoskeleton, spindle. During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
功能
developmental stage:During the cell cycle, levels increase and then remain constant until late mitosis after which they drop.,function:May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAD2L1BP family.,subcellular location:During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.,subunit:Interacts with MAD2L1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
