产品名称
MAN1B1 Rabbit Polyclonal Antibody
别名
MAN1B1; Endoplasmic reticulum mannosyl-oligosaccharide 1; 2-alpha-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1
蛋白名称
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11253
Human Swissprot No.
Q9UKM7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UKM7/entry
Mouse Swissprot No.
A2AJ15
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2AJ15
免疫原
Synthesized peptide derived from MAN1B1 . at AA range: 100-180
特异性
MAN1B1 Polyclonal Antibody detects endogenous levels of MAN1B1 protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011],
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
信号通路
N-Glycan biosynthesis;
功能
catalytic activity:Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).,cofactor:Calcium.,enzyme regulation:Inhibited by both 1-deoxymannojirimycin and kifunensine.,function:Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). The only product is the Man(8)GlcNAc(2) isomer B, the form lacking the middle-arm terminal alpha 1,2-mannose. It may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyl hydrolase 47 family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
