产品名称
mAChR M5 Rabbit Polyclonal Antibody
别名
CHRM5; Muscarinic acetylcholine receptor M5
蛋白名称
Muscarinic acetylcholine receptor M5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1133
Human Swissprot No.
P08912
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08912/entry
Mouse Swissprot No.
Q920H4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q920H4
免疫原
The antiserum was produced against synthesized peptide derived from human CHRM5. AA range:281-330
特异性
mAChR M5 Polyclonal Antibody detects endogenous levels of mAChR M5 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008],
组织表达
Brain,Keratinocyte,Lens epithelium,Placenta,Testis,
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;Regulates Actin and Cytoskeleton;
功能
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
