产品名称
mAChR M4 Rabbit Polyclonal Antibody
别名
CHRM4; Muscarinic acetylcholine receptor M4
蛋白名称
Muscarinic acetylcholine receptor M4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1132
Human Swissprot No.
P08173
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08173/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12672
Mouse Swissprot No.
P32211
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P32211
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25111
Rat Swissprot Link
http://www.uniprot.org/uniprot/P08485
免疫原
The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285
特异性
mAChR M4 Polyclonal Antibody detects endogenous levels of mAChR M4 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;Regulates Actin and Cytoskeleton;
功能
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
