产品名称
mAChR M1 Rabbit Polyclonal Antibody
别名
CHRM1; Muscarinic acetylcholine receptor M1
蛋白名称
Muscarinic acetylcholine receptor M1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1128
Human Swissprot No.
P11229
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P11229/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12669
Mouse Swissprot No.
P12657
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P12657
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25229
Rat Swissprot Link
http://www.uniprot.org/uniprot/P08482
免疫原
The antiserum was produced against synthesized peptide derived from human CHRM1. AA range:295-344
特异性
mAChR M1 Polyclonal Antibody detects endogenous levels of mAChR M1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;Regulates Actin and Cytoskeleton;
功能
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
