BD-PT2610

LZK Rabbit Polyclonal Antibody

MAP3K13; LZK; Mitogen-activated protein kinase kinase kinase 13; Leucine zipper-bearing kinase; Mixed lineage kinase; MLK

常规抗体

MAP3K13

Mitogen-activated protein kinase kinase kinase 13

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

9175

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9175

O43283

http://www.uniprot.org/uniprotkb/O43283/entry

71751

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71751

Q1HKZ5

http://www.uniprot.org/uniprot/Q1HKZ5

The antiserum was produced against synthesized peptide derived from human M3K13. AA range:151-200

LZK Polyclonal Antibody detects endogenous levels of LZK protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

108kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008],

Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.

Cytoplasm . Membrane ; Peripheral membrane protein .

MAPK_ERK_Growth;MAPK_G_Protein;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by autophosphorylation and homodimerization.,function:Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,sequence caution:Translated as Tyr.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.,tissue specificity:Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.