BD-PT2605

Lunatic Fringe Rabbit Polyclonal Antibody

LFNG; Beta-1; 3-N-acetylglucosaminyltransferase lunatic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

常规抗体

LFNG

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3955

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3955

Q8NES3

http://www.uniprot.org/uniprotkb/Q8NES3/entry

16848

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16848

O09010

http://www.uniprot.org/uniprot/O09010

170905

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170905

Q924T4

http://www.uniprot.org/uniprot/Q924T4

The antiserum was produced against synthesized peptide derived from human LFNG. AA range:121-170

Lunatic Fringe Polyclonal Antibody detects endogenous levels of Lunatic Fringe protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

42kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms

Kidney,

Golgi apparatus membrane ; Single-pass type II membrane protein .

Notch;

alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in LFNG are the cause of spondylocostal dysostosis autosomal recessive type 3 (SCDO3) [MIM:609813]. Autosomal recessive spondylocostal dysostosis is a rare condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.,function:Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.,online information:Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe,online information:GlycoGene database,PTM:A soluble form may be derived from the membrane form by proteolytic processing .,similarity:Belongs to the glycosyltransferase 31 family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.