产品名称
LT-β Rabbit Polyclonal Antibody
别名
LTB; TNFC; TNFSF3; Lymphotoxin-beta; LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4050
Human Swissprot No.
Q06643
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q06643/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16994
Mouse Swissprot No.
P41155
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P41155
免疫原
The antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230
特异性
LT-β Polyclonal Antibody detects endogenous levels of LT-β protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Membrane ; Single-pass type II membrane protein .
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
