产品名称
L-type Ca++ CP γ7 Rabbit Polyclonal Antibody
别名
CACNG7; Voltage-dependent calcium channel gamma-7 subunit; Neuronal voltage-gated calcium channel gamma-7 subunit; Transmembrane AMPAR regulatory protein gamma-7; TARP gamma-7
蛋白名称
Voltage-dependent calcium channel gamma-7 subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59284
Human Swissprot No.
P62955
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P62955/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81904
Mouse Swissprot No.
P62956
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62956
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140728
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62957
免疫原
The antiserum was produced against synthesized peptide derived from human CACNG7. AA range:198-247
特异性
L-type Ca++ CP γ7 Polyclonal Antibody detects endogenous levels of L-type Ca++ CP γ7 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium voltage-gated channel auxiliary subunit gamma 7(CACNG7) Homo sapiens The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010],
组织表达
Detected in heart left ventricle (PubMed:21127204). Widely expressed.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
