产品名称
L-type Ca++ CP γ1 Rabbit Polyclonal Antibody
别名
CACNG1; CACNLG; Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type; skeletal muscle calcium channel subunit gamma
蛋白名称
Voltage-dependent calcium channel gamma-1 subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=786
Human Swissprot No.
Q06432
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q06432/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12299
Mouse Swissprot No.
O70578
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70578
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29658
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97707
免疫原
The antiserum was produced against synthesized peptide derived from human CACNG1. AA range:137-186
特异性
L-type Ca++ CP γ1 Polyclonal Antibody detects endogenous levels of L-type Ca++ CP γ1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium voltage-gated channel auxiliary subunit gamma 1(CACNG1) Homo sapiens Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010],
细胞定位
Cell membrane, sarcolemma ; Multi-pass membrane protein .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
function:This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,tissue specificity:Skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
