产品名称
LTB4DH Rabbit Polyclonal Antibody
别名
PTGR1; LTB4DH; Prostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase
蛋白名称
Prostaglandin reductase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22949
Human Swissprot No.
Q14914
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14914/entry
Mouse Swissprot No.
Q91YR9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91YR9
免疫原
The antiserum was produced against synthesized peptide derived from human PTGR1. AA range:75-124
特异性
LTB4DH Polyclonal Antibody detects endogenous levels of LTB4DH protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],
组织表达
High expression in the kidney, liver, and intestine but not in leukocytes.
功能
catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.,catalytic activity:n-alkanal + NAD(P)(+) = alk-2-enal + NAD(P)H.,function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.,similarity:Belongs to the NADP-dependent oxidoreductase L4BD family.,subunit:Monomer or homodimer.,tissue specificity:High expression in the kidney, liver, and intestine but not in leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
