产品名称
Ephrin-A5 Rabbit Polyclonal Antibody
别名
EFNA5; EPLG7; LERK7; Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1946
Human Swissprot No.
P52803
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P52803/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13640
Mouse Swissprot No.
O08543
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08543
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116683
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97605
免疫原
Synthesized peptide derived from Ephrin-A5 . at AA range: 130-210
特异性
Ephrin-A5 Polyclonal Antibody detects endogenous levels of Ephrin-A5 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divi
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor . Membrane, caveola ; Lipid-anchor, GPI-anchor . Compartmentalized in discrete caveolae-like membrane microdomains.
功能
function:May function actively to stimulate axon fasciculation. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase.,similarity:Belongs to the ephrin family.,subcellular location:Compartmentalized in discrete caveolae-like membrane microdomains.,subunit:Binds to EPHB2 (By similarity). Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
