产品名称
LPAAT-θ Rabbit Polyclonal Antibody
别名
AGPAT9; GPAT3; MAG1; HMFN0839; Glycerol-3-phosphate acyltransferase 3; GPAT-3; 1-acylglycerol-3-phosphate O-acyltransferase 9; 1-AGP acyltransferase 9; 1-AGPAT 9; Acyl-CoA:glycerol-3-phosphate acyltransferase 3; hGPAT3; Lung cancer metastas
蛋白名称
Glycerol-3-phosphate acyltransferase 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84803
Human Swissprot No.
Q53EU6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q53EU6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231510
Mouse Swissprot No.
Q8C0N2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C0N2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305166
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4V8J4
免疫原
The antiserum was produced against synthesized peptide derived from human AGPAT9. AA range:381-430
特异性
LPAAT-θ Polyclonal Antibody detects endogenous levels of LPAAT-θ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012],
组织表达
Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
catalytic activity:Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,enzyme regulation:Inhibited by N-ethylmaleimide (NEM).,function:Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,tissue specificity:Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
