BD-PT2578

LOK Rabbit Polyclonal Antibody

STK10; LOK; Serine/threonine-protein kinase 10; Lymphocyte-oriented kinase

常规抗体

STK10

Serine/threonine-protein kinase 10

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6793

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6793

O94804

http://www.uniprot.org/uniprotkb/O94804/entry

O55098

http://www.uniprot.org/uniprot/O55098

The antiserum was produced against synthesized peptide derived from human STK10. AA range:491-540

LOK Polyclonal Antibody detects endogenous levels of LOK protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

120kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008],

Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Cell membrane ; Peripheral membrane protein .

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed predominantly in lymphoid organs.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.