产品名称
LMX1B Rabbit Polyclonal Antibody
别名
LMX1B; LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
蛋白名称
LIM homeobox transcription factor 1-beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4010
Human Swissprot No.
O60663
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60663/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16917
Mouse Swissprot No.
O88609
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88609
免疫原
The antiserum was produced against synthesized peptide derived from human LMX1B. AA range:126-175
特异性
LMX1B Polyclonal Antibody detects endogenous levels of LMX1B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
LIM homeobox transcription factor 1 beta(LMX1B) Homo sapiens This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
组织表达
Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets.
功能
disease:Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also knowan as Onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia.,function:Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,tissue specificity:Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
