产品名称
DSC1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1823
Human Swissprot No.
Q08554
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q08554/entry
Mouse Swissprot No.
P55849
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P55849
免疫原
Synthesized peptide derived from human DSC1 AA range: 749-799
特异性
This antibody detects endogenous levels of DSC1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015],
组织表达
Strongly expressed in epidermis, less in lymph node and tongue.
细胞定位
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
功能
domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.,similarity:Contains 5 cadherin domains.,tissue specificity:Strongly expressed in epidermis, less in lymph node and tongue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
