产品名称
LHX1 Rabbit Polyclonal Antibody
别名
LHX1; LIM-1; LIM1; LIM/homeobox protein Lhx1; LIM homeobox protein 1; Homeobox protein Lim-1; hLim-1
蛋白名称
LIM/homeobox protein Lhx1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3975
Human Swissprot No.
P48742
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48742/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16869
Mouse Swissprot No.
P63006
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63006
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=257634
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63007
免疫原
Synthesized peptide derived from the Internal region of human LHX1.
特异性
LHX1 Polyclonal Antibody detects endogenous levels of LHX1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010],
组织表达
Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines.
功能
domain:The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox.,function:Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Interacts with LDB1 via the tandem LIM domains.,tissue specificity:Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
