产品名称
LHR Rabbit Polyclonal Antibody
别名
LHCGR; LCGR; LGR2; LHRHR; Lutropin-choriogonadotropic hormone receptor; LH/CG-R; Luteinizing hormone receptor; LHR; LSH-R
蛋白名称
Lutropin-choriogonadotropic hormone receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3973
Human Swissprot No.
P22888
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P22888/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16867
Mouse Swissprot No.
P30730
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30730
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25477
Rat Swissprot Link
http://www.uniprot.org/uniprot/P16235
免疫原
The antiserum was produced against synthesized peptide derived from human LSHR. AA range:621-670
特异性
LHR Polyclonal Antibody detects endogenous levels of LHR protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008],
组织表达
Gonadal and thyroid cells.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
alternative products:Additional isoforms seem to exist,disease:Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.,disease:Defects in LHCGR are a cause of Leydig cell hypoplasia (LCH) [MIM:152790]. LCH is an autosomal recessive disease characterized by male pseudohermaphroditism. In LCH the testes are small with marked immaturity of the Leydig cells which correlates with undetectable plasma testosterone levels and elevated gonadotropins.,function:Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.,similarity:Contains 7 LRR (leucine-rich) repeats.,tissue specificity:Gonadal and thyroid cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
