BD-PT2544-LBP Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

LBP Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT2544

产品名称

LBP Rabbit Polyclonal Antibody

别名

LBP; Lipopolysaccharide-binding protein; LBP

类别

常规抗体

基因名称

LBP

蛋白名称

Lipopolysaccharide-binding protein

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

3929

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3929

Human Swissprot No.

P18428

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P18428/entry

Mouse Gene ID

16803

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16803

Mouse Swissprot No.

Q61805

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q61805

Rat Swissprot No.

Q63313

Rat Swissprot Link

http://www.uniprot.org/uniprot/Q63313

免疫原

The antiserum was produced against synthesized peptide derived from human LBP. AA range:221-270

特异性

LBP Polyclonal Antibody detects endogenous levels of LBP protein.

稀释度

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

预测分子量

53kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

lipopolysaccharide binding protein(LBP) Homo sapiens The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012],

组织表达

Detected in blood serum (at protein level).

细胞定位

Secreted . Cytoplasmic granule membrane . Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. .

信号通路

Toll_Like;

功能

function:Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor.,similarity:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Immunohistochemical analysis of paraffin-embedded Human liver. 1, Antibody was diluted at 1:100（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.