产品名称
Latrophilin-1 Rabbit Polyclonal Antibody
别名
LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22859
Human Swissprot No.
O94910
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O94910/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=330814
Mouse Swissprot No.
Q80TR1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80TR1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65096
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88917
免疫原
The antiserum was produced against synthesized peptide derived from human LPHN1. AA range:561-610
特异性
Latrophilin-1 Polyclonal Antibody detects endogenous levels of Latrophilin-1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],
组织表达
Brain,Lung,T-cell,Whole embryo,
细胞定位
Cell membrane; Multi-pass membrane protein. Cell projection, axon . Cell projection, growth cone . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, synaptosome . Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. .
功能
domain:The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.,function:Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
