产品名称
LAP1B Rabbit Polyclonal Antibody
别名
TOR1AIP1; Torsin-1A-interacting protein 1; Lamin-associated protein 1B; LAP1B
蛋白名称
Torsin-1A-interacting protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26092
Human Swissprot No.
Q5JTV8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5JTV8/entry
Mouse Swissprot No.
Q921T2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q921T2
免疫原
The antiserum was produced against synthesized peptide derived from human TOR1AIP1. AA range:431-480
特异性
LAP1B Polyclonal Antibody detects endogenous levels of LAP1B protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016],
组织表达
Expressed in muscle, liver and kidney.
细胞定位
Nucleus inner membrane ; Single-pass membrane protein .
功能
function:Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TOR1AIP family.,subunit:Interacts with TOR1A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
