BD-PT2527

Laminin α-5 Rabbit Polyclonal Antibody

LAMA5; KIAA0533; KIAA1907; Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha

常规抗体

LAMA5

Laminin subunit alpha-5

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3911

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3911

O15230

http://www.uniprot.org/uniprotkb/O15230/entry

16776

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16776

Q61001

http://www.uniprot.org/uniprot/Q61001

The antiserum was produced against synthesized peptide derived from human LAMA5. AA range:2381-2430

Laminin α-5 Polyclonal Antibody detects endogenous levels of Laminin α-5 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

400kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013],

Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.

Secreted, extracellular space, extracellular matrix, basement membrane. Major component.

Focal adhesion;ECM-receptor interaction;Pathways in cancer;Small cell lung cancer;

domain:Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.,function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.,similarity:Contains 1 laminin IV type A domain.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 22 laminin EGF-like domains.,similarity:Contains 5 laminin G-like domains.,subcellular location:Major component.,subunit:Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3) which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.,tissue specificity:Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.