BD-PC0074

Cleaved-Spectrin α II (D1185) Rabbit Polyclonal Antibody

SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit

常规抗体

SPTAN1

Spectrin alpha chain non-erythrocytic 1

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6709

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6709

Q13813

http://www.uniprot.org/uniprotkb/Q13813/entry

P16546

http://www.uniprot.org/uniprot/P16546

The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

137kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

Aorta,Brain,Epithelium,Fetal brain,Fetal brain cortex,Fetal liver,L

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. .

Tight junction;

function:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.,PTM:Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.,similarity:Belongs to the spectrin family.,similarity:Contains 1 SH3 domain.,similarity:Contains 23 spectrin repeats.,similarity:Contains 3 EF-hand domains.,subunit:Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.