产品名称
KV3.2 Rabbit Polyclonal Antibody
别名
KCNC2; Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel Kv3.2
蛋白名称
Potassium voltage-gated channel subfamily C member 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3747
Human Swissprot No.
Q96PR1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96PR1/entry
Mouse Swissprot No.
Q14B80
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q14B80
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246153
Rat Swissprot Link
http://www.uniprot.org/uniprot/P22462
免疫原
The antiserum was produced against synthesized peptide derived from human Potassium Channel Kv3.2b. AA range:589-638
特异性
KV3.2 Polyclonal Antibody detects endogenous levels of KV3.2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],
细胞定位
Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, synaptosome . Cell junction, synapse . Apical cell membrane . Basolateral cell membrane . Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites. .
功能
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
