BD-PT2505

KV1.1 Rabbit Polyclonal Antibody

KCNA1; Potassium voltage-gated channel subfamily A member 1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1

常规抗体

KCNA1

Potassium voltage-gated channel subfamily A member 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3736

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3736

Q09470

http://www.uniprot.org/uniprotkb/Q09470/entry

16485

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16485

P16388

http://www.uniprot.org/uniprot/P16388

24520

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24520

P10499

http://www.uniprot.org/uniprot/P10499

The antiserum was produced against synthesized peptide derived from human KCNA1. AA range:256-305

KV1.1 Polyclonal Antibody detects endogenous levels of KV1.1 protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

57kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008],

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673).

Cell membrane ; Multi-pass membrane protein . Membrane . Cell projection, axon . Cytoplasmic vesicle . Perikaryon . Endoplasmic reticulum . Cell projection, dendrite . Cell junction . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, presynapse . Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). .

disease:Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1) [MIM:160120]; also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent.,disease:Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1) [MIM:160120]. Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance.,domain:The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,PTM:Palmitoylated on Cys-243; which may be required for membrane targeting.,RNA editing:Partially edited. RNA editing varies from 17% in the caudate nucleus to 68% in the spinal cord and to 77% in the medulla.,similarity:Belongs to the potassium channel family. A (Shaker) subfamily.,subunit:Heterotetramer of potassium channel proteins. Binds KCNAB2 and PDZ domains of DLG1, DLG2 and DLG4.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.