产品名称
KOR-1 Rabbit Polyclonal Antibody
别名
OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
蛋白名称
Kappa-type opioid receptor
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4986
Human Swissprot No.
P41145
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P41145/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18387
Mouse Swissprot No.
P33534
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P33534
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29335
Rat Swissprot Link
http://www.uniprot.org/uniprot/P34975
免疫原
The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370
特异性
KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],
组织表达
Detected in brain and placenta.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.,online information:Kappa opioid receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R1. Interacts with GABARAPL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
