产品名称
KLF7 Rabbit Polyclonal Antibody
别名
KLF7; UKLF; Krueppel-like factor 7; Ubiquitous krueppel-like factor
蛋白名称
Krueppel-like factor 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8609
Human Swissprot No.
O75840
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75840/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93691
Mouse Swissprot No.
Q99JB0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JB0
免疫原
The antiserum was produced against synthesized peptide derived from human KLF7. AA range:171-220
特异性
KLF7 Polyclonal Antibody detects endogenous levels of KLF7 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
功能
domain:The acidic N-terminal part may favor interaction with the basic domain of transcription factors.,function:Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
