产品名称
KIR3.4 Rabbit Polyclonal Antibody
别名
KCNJ5; GIRK4; G protein-activated inward rectifier potassium channel 4; GIRK-4; Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel; inwardly rectifying subfamily J membe
蛋白名称
G protein-activated inward rectifier potassium channel 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3762
Human Swissprot No.
P48544
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48544/entry
Mouse Swissprot No.
P48545
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48545
免疫原
The antiserum was produced against synthesized peptide derived from human KCNJ5. AA range:370-419
特异性
KIR3.4 Polyclonal Antibody detects endogenous levels of KIR3.4 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008],
组织表达
Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
function:This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.,tissue specificity:Islets, exocrine pancreas and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
