产品名称
KEPI Rabbit Polyclonal Antibody
别名
PPP1R14C; KEPI; Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81
蛋白名称
Protein phosphatase 1 regulatory subunit 14C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81706
Human Swissprot No.
Q8TAE6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TAE6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76142
Mouse Swissprot No.
Q8R4S0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4S0
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171010
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8R4R9
免疫原
The antiserum was produced against synthesized peptide derived from human PPP1R14C. AA range:51-100
特异性
KEPI Polyclonal Antibody detects endogenous levels of KEPI protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010],
组织表达
Detected in breast cancer.
细胞定位
Cytoplasm . Membrane ; Peripheral membrane protein .
功能
function:Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in breast cancer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
