BD-PT2462

KDEL Receptor 2 Rabbit Polyclonal Antibody

KDELR2; ERD2.2; ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2

常规抗体

KDELR2

ER lumen protein retaining receptor 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

11014

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11014

P33947

http://www.uniprot.org/uniprotkb/P33947/entry

66913

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66913

Q9CQM2

http://www.uniprot.org/uniprot/Q9CQM2

304290

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304290

Q5U305

http://www.uniprot.org/uniprot/Q5U305

The antiserum was produced against synthesized peptide derived from human ERD22. AA range:81-130

KDEL Receptor 2 Polyclonal Antibody detects endogenous levels of KDEL Receptor 2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

24kD

-20°C/1 year

Polyclonal, Rabbit,IgG

KDEL endoplasmic reticulum protein retention receptor 2(KDELR2) Homo sapiens Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing r

Brain,Placenta,Skin,Testis,Uterus,

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein . Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. .

Vibrio cholerae infection;

function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.,similarity:Belongs to the ERD2 family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.