产品名称
KCNT1 Rabbit Polyclonal Antibody
别名
KCNT1; KIAA1422; Potassium channel subfamily T member 1; KCa4.1
蛋白名称
Potassium channel subfamily T member 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57582
Human Swissprot No.
Q5JUK3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5JUK3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=227632
Mouse Swissprot No.
Q6ZPR4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZPR4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60444
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z258
免疫原
The antiserum was produced against synthesized peptide derived from human KCNT1. AA range:1019-1068
特异性
KCNT1 Polyclonal Antibody detects endogenous levels of KCNT1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
组织表达
Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).,PTM:Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.,similarity:Belongs to the potassium channel family. Calcium-activated subfamily.,similarity:Contains 1 RCK N-terminal domain.,subunit:Interacts with CRBN via its cytoplasmic C-terminus.,tissue specificity:Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
