BD-PT2456

KCNH1 Rabbit Polyclonal Antibody

KCNH1; EAG; EAG1; Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1

常规抗体

KCNH1

Potassium voltage-gated channel subfamily H member 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3756

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3756

O95259

http://www.uniprot.org/uniprotkb/O95259/entry

16510

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16510

Q60603

http://www.uniprot.org/uniprot/Q60603

65198

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65198

Q63472

http://www.uniprot.org/uniprot/Q63472

The antiserum was produced against synthesized peptide derived from human KCNH1. AA range:720-769

KCNH1 Polyclonal Antibody detects endogenous levels of KCNH1 protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

110kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided

Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic density membrane . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.

disease:Overexpression of EAG may confer a growth advantage to cancer cells and favor tumor cell proliferation.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B.,tissue specificity:Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.